Romidepsin Catalog No.:M8157-10 GluR1 trafficking

GluR1 trafficking

with an average cytostatic IC50 of >60 microM in 15 cell types

inhibition of Aurora kinase activity by ZM-447439 results in abnormalities during mitosis by regulating the phosphorylation of histone H3 serine 10 (H3S10Ph) from G2 to metaphase with different perturbations in each embryonic cycle

p53 is not enzymatically degraded and the transcriptional activity of p53 is restored

2019 May 2

Romidepsin Catalog No.:M8157-10 GluR1 traffickingRomidepsin, also known as FK228; is a bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with antineoplastic activity. After intracellular activation, romidepsin binds to and inhibits histone deacetylase (HDAC), resulting in alterations in gene expression and the induction of cell differentiation, cell cycle arrest, and apoptosis. This agent also inhibits hypoxia induced angiogenesis and depletes several heat shock