Candesartan (Cilexetil) 751 3 mg/mL (335

3 mg/mL (335

Smiles: CC1C=C(C=NC=1)C1=CC(C(=O)NCC2=CC=C(OC)C(=N2)OC)=C(C=N1)C1=NC=CS1

) (Note: PYR-41 in solution may exist as a mixture of E- and Z- isomers

>5000 mg/kg bwt by the dermal route

Chemical Name: (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1

Candesartan (Cilexetil) 751 3 mg/mL (335Candesartan cilexetil is a prodrug of the potent, long acting, and selective angiotensin II type 1 receptor (AT1) antagonist, candesartan. It is rapidly hydrolyzed to candesartan during gastrointestinal absorptio. Candesartan blocks the vasoconstrictor and aldosterone secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its