Clemizole Hydrochloride 2 a potent antioxidant with anticancer activities vasorelaxing
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Clemizole Hydrochloride 2 a potent antioxidant with anticancer activities vasorelaxingClemizole, also known as AL 20, P 48, or Reactrol, is a potent inhibitor of transient receptor potential channel TRPC5. Clemizole efficiently blocks TRPC5 currents and Ca(2+) entry in the low micromolar range (IC50 = 1. 0 1. 3 M). Clemizole blocks TRPC5 currents irrespectively of the mode of activation. Based on fluorometric [Ca(2+)]i measurements, clemizole exhibits a sixfold selectivity for TRPC5 over TRPC4 (IC50 = 6. 4 M). Clemizole was not only
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