Dabrafenib - CAS# 1195765-45-7 size:10mg solid PubMed PMID: 29304833

PubMed PMID: 29304833

named after the polo gene of Drosophila melanogaster

1021/cb2002413

correlates with CK2α mRNA and protein levels but not the CK2α' catalytic subunit

It possesses tumor-specific effect

Dabrafenib - CAS# 1195765-45-7 size:10mg solid PubMed PMID: 29304833Dabrafenib, CAS No. 1195765 45 7, also known as GSK2118436 , is an orally bioavailable inhibitor of B raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B raf belongs to the the raf mil family of serine threonine protein kinases and plays a role in regulating the MAP kinase ERKs signaling