E6446 oxyguanosine antiproliferative activity

antiproliferative activity

Chemical Name: 6H-Thieno[3

71(23):7238-49

LD50: Mice 55mg/kg (i

Chemical Name: 2-(furan-2-ylmethylsulfinyl)-N-[(Z)-4-[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxybut-2-enyl]acetamide

E6446 oxyguanosine antiproliferative activityE6446 inhibits Toll like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine phosphate guanidine (CpG) containing DNA, which stimulates TLR9. Product information CAS Number: 1219925 73 1 Molecular Weight: 449. 59 Formula: C27H35N3O3 Synonym: E 6446 Chemical Name: 6 [3 (pyrrolidin 1