EN460 lol 24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9

24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9

Temsirolimus treatment at 10 mg/kg/day produces a decrease in peripheral blood blasts and in splenomegaly

The high BLU-554 liver-to-plasma ratio suggests there is a relatively high amount of the drug being transported into the liver

1435467-37-0

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EN460 lol 24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9EN460 is an endoplasmic reticulum oxidoreductase (ERO1) inhibitor. EN460 showed a dose response effect on the embryos with a dose of 10 M being significantly lethal during early embryonic development. Product information CAS Number: 496807 64 8 Molecular Weight: 460. 79 Formula: C22H12ClF3N2O4 Chemical Name: 2 chloro 5 [(4Z) 5 oxo 4 [(5 phenylfuran 2 yl)methylidene] 3 (trifluoromethyl) 4,5 dihydro 1H pyrazol 1 yl]benzoic acid Smiles: