PND-1186 Catalog No.:M9572-10 Fiedler MA

Fiedler MA

is a potent and selective Smurf1 E3 ubiquitin ligase inhibitor with Kd ~3

GW-9662 has nanomolar IC50 versus PPARγ and is 10- and 600-fold less potent in binding experiments using PPARα and PPARδ

ZLN024 activates AMPK in L6 myotubes and stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio

is a highly potent and selective small molecule inhibitor of histone methyltransferase EZH2

PND-1186 Catalog No.:M9572-10 Fiedler MAPND 1186, also known as SR 2156 and VS 4718, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1. 5 nM in vitro. PND 1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1. 0 M PND 1186 (>5 fold above IC50) had limited effects on cell proliferation. However, under non adherent conditions as spheroids and as colonies in soft agar, 0. 1 M PND 1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase 3