LHW090-A7 - CAS# 1308256-94-1 Catalog No.:M6427-10 Identification of a chemical probe

Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit

It acts most likely as a result of combined inhibition of DYRK1A and GSK3B

PYR-41 also mediated cross-linking of specific protein kinases (Bcr-Abl

G-749 shows strong inhibitory activity with IC50 of

is a potent inhibitor of ferroptosis with an EC50 ~60 nM

LHW090-A7 - CAS# 1308256-94-1 Catalog No.:M6427-10 Identification of a chemical probeLHW090 A7, CAS No. 1308256 94 1, is a compound developed as an inhibitor of neutral endopeptidase (NEP), an enzyme responsible for the metabolic inactivation of enkephalins. 1 Inhibitors of NEP have been shown to increase plasma levels of endogenous atrial natriuretic peptides and, as such, are expected to induce natriuretic and diuretic effects. Product information CAS Number: 1308256 94 1 Molecular Weight: 375. 85 Formula: C20H22ClNO4 Synonym: