Tecovirimat - CAS# 869572-92-9 aftor (benzenesulfonate) Jończyk J

Jończyk J

Preclinical studies demonstrated the successful inhibition of IL-12 and IL-23 production by the drug

5 MTD dose compared with a 0

A significant dose-dependent inhibition of xenograft growth in mice is observed following SR18662 treatment that exceeds the effect of ML264 at equivalent doses

is a functionalized cereblon ligand for PROTAC® research and development

Tecovirimat - CAS# 869572-92-9 aftor (benzenesulfonate) Jończyk JTecovirimat, also known as SIGA 246 and ST 246, is a core protein cysteine protease inhibitor potentially for treatment of smallpox infection. Tecovirimat is a novel antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat has shown efficacy in all small animal and nonhuman primate prophylaxis and therapeutic efficacy models of poxvirus induced disease tested to date. Product information CAS Number: