Diphylline ntin) 5-trien-7-yl]methyl}((²H₃)methyl)amino)propyl]-7

5-trien-7-yl]methyl}((²H₃)methyl)amino)propyl]-7

As a result DNA replication and transcription is inhibited

The pyridine regio-isomer GSK-J2 displays significantly less on-target activity (IC50 > 100 µM for human JmjD3) and thus can be used as control for target effects in vitro

2414909-94-5

InChi: InChI=1S/C58H82N8O14S2/c1-37-49(81-35-61-37)41-13-9-39(10-14-41)29-59-53(71)45-27-43(67)31-65(45)55(73)51(57(3

Diphylline ntin) 5-trien-7-yl]methyl}((²H₃)methyl)amino)propyl]-7Dyphylline is a phosphodiesterase inhibitor used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. It also acts as an adenosine receptor antagonist. Dyphilline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other