Dexrazoxane rynoxine B inhibition of tubulin function as

inhibition of tubulin function as well as protein and enzyme synthesis

and is also being investigated for potential application against Lassa fever and Ebola virus disease

Billingsley KL

Clanachan AS

1]nonacosa-4

Dexrazoxane rynoxine B inhibition of tubulin function asDexrazoxane is a bisdioxopiperazine with iron chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical generating anthracycline iron complexes, which may minimize anthracycline iron complex mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the