NMS-873 - ATPase VCP/p97 Inhibitor. CAS# 1418013-75-8 0321 Solubility: DMSO: ≥ 45 mg/mL

Solubility: DMSO: ≥ 45 mg/mL

selective and cell permeable HDAC3 inhibitor

Smiles: CC(C)(C(=O)N[C@H]1C2=CC=CC=C2C2=CC=CC=C2NC1=O)C(=O)NCC(F)(F)C(F)(F)F

We monitored the effect of GNF-2 with AKIs on the proliferation and clonigenicity of the different Ba/F3 cells

The corresponding cAC10-L4-MMAF4 ADC was much less toxic

NMS-873 - ATPase VCP/p97 Inhibitor. CAS# 1418013-75-8 0321 Solubility: DMSO: ≥ 45 mg/mLNMS 873, CAS NO. 1418013 75 8, is a potent and specific small molecule allosteric inhibitor of the ATPase VCP p97 (IC50 ~0. 03 M), identified by a high throughput screening. It is very selective (IC50 >10 M) against all of the AAA ATPases, HSP90 or the 53 kinases tested. Using photo affinity labeling, structural analysis and mutagenesis, the binding site of NMS 873 was found to be a region spanning the D1 and D2 domains of adjacent protomers