CZC-25146 Hydrochloride 8644 (R) Daun02 may be useful as

Daun02 may be useful as a prodrug-activating enzyme in suicide gene therapy and has the potential to increase the selective toxicity of conventional antitumor agents

By itself effectiveness for this purpose is between 66% and 90%

CC1=CC(N)=C2C=CC=CC2=[N+]1CCCCCCCCCC[N+]1=C2C=CC=CC2=C(N)C=C1C

but Pirinixic acid shows no effects in PPAR-α silenced cells

Smiles: OC(=O)CCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O

CZC-25146 Hydrochloride 8644 (R) Daun02 may be useful asCZC 25146 is a potent and selective LRRK2 inhibitor. Leucine rich repeat kinase 2 (LRRK2) mutations are the most important cause of familial Parkinson's disease. CZC 25146 prevents mutant LRRK2 induced injury of cultured rodent and human neurons with mid nanomolar potency. Product information CAS Number: 1330003 04 7 Molecular Weight: 525. 00 Formula: C22H26ClFN6O4S Chemical Name: N {2 [(5 fluoro 2 {[2 methoxy 4 (morpholin 4 yl)phenyl]amino}pyrimidin