GRP-60367 - CAS# 1309241-34-6 072 424(1):47-60

424(1):47-60

InChi: InChI=1S/C20H22O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20

Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity

As LSD1 plays an important role in the epigenetic control of gene expression in normal development and cancer progression

with an IC50 of 6

GRP-60367 - CAS# 1309241-34-6 072 424(1):47-60GRP 60367, CAS No. 1309241 34 6, is a potent and selective rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP 60367 inhibits entry of a subset of RABV strains. Resistance profiling of the chemotype revealed hot spots in conserved hydrophobic positions of the RABV G protein fusion loop that were confirmed in transient cell to cell fusion assays. Transfer of RABV G genes with signature resistance mutations into a