ML364 - CAS# 1991986-30-1 60135 and pancreatic and breast cancers)
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ML364 - CAS# 1991986-30-1 60135 and pancreatic and breast cancers)ML364, CAS No. 1991986 30 1, is a small molecule inhibitor of the deubiquitinase USP2 with potential anticancer activity. ML364 has an IC50 of 1. 1 m in a biochemical assay using an internally quenched fluorescent di ubiquitin substrate. Direct binding of ML364 to USP2 was demonstrated using microscale thermophoresis. ML364 induced an increase in cellular cyclin D1 degradation and caused cell cycle arrest as shown in Western blottings and flow
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