VLX1570 - CAS# 1431280-51-1 size:10mg solid Nifedipine and AP-3 on primary

Nifedipine and AP-3 on primary cultures of cerebellar granule cells in an oxygen-glucose deprivation model

Smiles: CC(C)(C)OC(=O)C1=CN=C(C=C1)N1NC=C(C1=O)N1C=CN=N1

6 mg/kg/day

NAALADase inhibitor

2015 Dec 18:1-12

VLX1570 - CAS# 1431280-51-1 size:10mg solid Nifedipine and AP-3 on primaryVLX1570, CAS No. 1431280 51 1, is an inhibitor of the 19S proteasome specific deubiquitylating enzymes (DUBs) USP14 and UCHL5, with apoptosis inducing and antineoplastic activities. Upon administration, VLX1570 specifically binds to both USP14 and UCHL5, thereby blocking their deubiquitylating activity. This blocks the ubiquitin proteasome degradation pathway, prevents the degradation of defective proteins, and leads to an accumulation of poly