Siramesine 779 MDV-3100 shows dose-independent pharmacokinetics at

MDV-3100 shows dose-independent pharmacokinetics at intravenous and oral doses of 0

CAS Number: 197890-44-1

(2003) Mol Cancer Ther

InChiKey: IAFNAEGXTKTGHN-UHFFFAOYSA-N

Aldoxorubicin binds selectively to the cysteine-34 position of albumin via its maleimide moiety

Siramesine 779 MDV-3100 shows dose-independent pharmacokinetics atSiramesine, also known as Lu 28 179, is a potent sigma 2 receptor agonist. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Siramesine involves lysosomal leakage and oxidative stress. Product information CAS Number: 147817 50 3 Molecular Weight: 454. 58 Formula: C30H31FN2O Chemical Name: 1' {4 [1 (4 fluorophenyl)