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BIBW2992(Afatinib) - EGFR Inhibitor. CAS# 439081-18-2 Catalog No.:M60065-10S Formula: C19H17NO3

BIBW2992(Afatinib) - EGFR Inhibitor. CAS# 439081-18-2 Catalog No.:M60065-10S Formula: C19H17NO3

Name: BIBW2992(Afatinib) - EGFR Inhibitor. CAS# 439081-18-2 Catalog No.:M60065-10S Formula: C19H17NO3
Brand: gaabil.dk
SKU: 55625555825
Price: 21.00 USD
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BIBW2992(Afatinib) - EGFR Inhibitor. CAS# 439081-18-2 Catalog No.:M60065-10S Formula: C19H17NO3BIBW2992 (Afatinib), CAS No. 439081 18 2, is a highly potent and selective irreversible EGFR inhibitor, inhibiting EGFRwt, EGFRL858R, EGFRL858R T790M and HER2 with IC50 of 0. 5 nM, 0. 4 nM, 10 nM, 14 nM, respectively. BIBW2992 suppresses transformation in isogenic cell based assays, inhibits survival of cancer cell lines, exhibits potent effects on both EGFR and HER2 phosphorylation, and induces tumor regression in xenograft and transgenic lung cancer

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Formula: C19H17NO3

Elayne Chan-Penebre

but also shows better efficacy in inhibiting cancer cell proliferation than each drug alone

These culture conditions do not include xenobiotic supplements

412:211-221

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