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P5091 - Ubiquitin-specific Protease 7 (USP7) Inhibitor. CAS# 882257-11-6 size:2 mg solid visible nuclei and more noticeable

SKU: 54414033520

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PLN45.00 PLN84.00

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P5091 - Ubiquitin-specific Protease 7 (USP7) Inhibitor. CAS# 882257-11-6 size:2 mg solid visible nuclei and more noticeableP5091 (P005091), CAS No. 882257 11 6, is a novel potent and selective inhibitor of ubiquitin specific protease 7 (USP7) with an IC50 ~4. 2 M. It does not inhibit other DUBs or other families of cysteine proteases tested (EC50 > 100 mM). It induces apoptosis in MM cells resistant to conventional and bortezomib therapies. Biochemical and genetic studies showed that blockade of HDM2 and p21 abrogated P5091 induced cytotoxicity. In animal tumor model

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Description

visible nuclei and more noticeable bile canaliculi between hepatocytes

71(5):1573-83

and indicates very good penetration to the brain

BQU57 that blocks Ral function would be valuable as research tools and for cancer therapeutics

02 μM for Hep 3B

P5091 - Ubiquitin-specific Protease 7 (USP7) Inhibitor. CAS# 882257-11-6 size:2 mg solid visible nuclei and more noticeableP5091 (P005091), CAS No. 882257 11 6, is a novel potent and selective inhibitor of ubiquitin specific protease 7 (USP7) with an IC50 ~4. 2 M. It does not inhibit other DUBs or other families of cysteine proteases tested (EC50 > 100 mM). It induces apoptosis in MM cells resistant to conventional and bortezomib therapies. Biochemical and genetic studies showed that blockade of HDM2 and p21 abrogated P5091 induced cytotoxicity. In animal tumor model

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