CUDC-101 - HDAC/EGFR/HER2 Inhibitor. CAS# 1012054-59-9 Catalog No.:M60092-2S 12(7):531-8

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CUDC-101 - HDAC/EGFR/HER2 Inhibitor. CAS# 1012054-59-9 Catalog No.:M60092-2S 12(7):531-8CUDC 101, CAS No. 1012054 59 9, is a potent multi target inhibitor targeting HDAC, EGFR and HER2 with IC50 of 4. 4 nM, 2. 4 nM, and 15. 7 nM, respectively. It is specific for class I and class II HDACs, not for class III Sir type HDACs, and has > 50 fold selectivity against other protein kinases. CUDC 101 displays broad antiproliferative activity in many human cancer cell types with IC50 of 0. 04 0. 80 M, exhibiting a higher potency than erlotinib,

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