SB505124 - CAS# 694433-59-5 0022 Cell outgrowth from explants dissected

Cell outgrowth from explants dissected from eyes to which SB505124 is applied during GFS is robust while outgrowth is poor from those treated with MMC

Afuresertib hydrochloride

hydrochloride is an oral bioavailabile TGF-beta signaling agonist

Nicholson JR

(2009) Nature

SB505124 - CAS# 694433-59-5 0022 Cell outgrowth from explants dissectedSB505124, CAS No. 694433 59 5, is a selective inhibitor of transforming growth factor type I receptor (ALK5, ALK4 and ALK7) with potential anticancer activity. SB505124 selectively inhibits signaling from TGF and activin; does not inhibit other ALK family members. SB 505124 selectively and concentration dependently inhibits ALK4 , ALK5 , and ALK 7 dependent activation of downstream cytoplasmic signal transducers, Smad2 and Smad3, and of TGF beta