Istaroxime Hydrochloride Size:Solid 10 mg Smiles: C=CC1=CC(O)=CC2N=C(OC=21)C1=CC(F)=C(O)C=C1

Smiles: C=CC1=CC(O)=CC2N=C(OC=21)C1=CC(F)=C(O)C=C1

Smiles: NC1=NC=NC2=C1C(COC1C=C(Cl)C=CC=1)=NN2C1CCOCC1

135(5):457-461

Smiles: CC(C)(C)OC(=O)N[C@H]([C@@H](O)C(=O)O[C@H]1C[C@@]2(O)[C@@H](OC(=O)C3C=CC=CC=3)[C@@H]3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C(=O)C(=O)C(=C1C)C2(C)C)OC(C)=O)C1C=CC=CC=1

is an inhibitor of ATP synthase

Istaroxime Hydrochloride Size:Solid 10 mg Smiles: C=CC1=CC(O)=CC2N=C(OC=21)C1=CC(F)=C(O)C=C1Istaroxime, also known as PST 2744, is a positive inotropic agent that mediates its action through inhibition of sodium potassium adenosine triphosphatase (Na+ K+ ATPase). Na+ K+ ATPase inhibition increases intracellular sodium levels, which reverses the driving force of the sodium calcium exchanger, inhibiting calcium extrusion and possibly facilitating calcium entry. Additionally, Istaroxime increases intracellular calcium by improving the efficacy