LY315920(Varespladib) iglinide Calcium PubMed Central PMCID: PMC4147329

PubMed Central PMCID: PMC4147329

TH-302 was intraperitoneally (IP) dosed to mice at 50 mg/kg once per day to inhibit tumor growth

Pomalidomide4PEG1acid

CAS Number: 852947-39-8

FAK signaling in human cancer as a target for therapeutics

LY315920(Varespladib) iglinide Calcium PubMed Central PMCID: PMC4147329Varespladib, aslo known as LY315920, is a secreted phospholipase A2 (sPLA2) inhibitor (IC50 = 50 750 nM for a range of sPLA2 isoforms). Varespladib reduces atherosclerosis and aneurysm formation in ApoE mice and in guinea pigs. Varespladib significantly reduces the post ACS inflammatory response in those with and without diabetes. Varespladib may be potentially useful for treatment of coronary artery disease. Product information CAS Number: 172732 68