K-Ras G12C-IN-3 Catalog No.:M8513-10 2013 Oct 15

2013 Oct 15

Probe ML188 is a modest molecular weight SARS-CoV 3CLpro inhibitor with demonstrated antiviral activity and a non-covalent mechanism of action

Formula: C20H24FN5O3

It inhibits PHD2 via binding to the 2OG binding site

Formula: C31H32N4O3

K-Ras G12C-IN-3 Catalog No.:M8513-10 2013 Oct 15K Ras G12C IN 3 is a novel and irreversible inhibitor of mutant K ras G12C. IC50 value: Target: K ras G12C inhibitorFor more information, please see the following patent. Heterocyclic compounds as covalent inhibitors of G12C mutant K Ras protein useful for treating cancers, and preparation thereofBy Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao From PCT Int. Appl. (2014), WO 2014152588 A1 20140925. Product information CAS Number: 1629268 19