ML277 - CAS# 1401242-74-7 size:10mg solid CAS Number: 418805-02-4

CAS Number: 418805-02-4

Each library contains 2 or 5 mg of listed compounds in that category in separated vials in DMSO at the concentration of 10 mM or in solid format

InChiKey: AAAQFGUYHFJNHI-SFHVURJKSA-N

Smiles: NC1=NC=C(N=C1C(=O)NC1=CN=CC=C1N1CCC(CC1)C(O)=O)C1C=CC=CC=1

Defactinib (VS-6063) doses of 25 mg/kg twice a day or greater statistically significantly inhibits pFAK (Tyr397) at 3 hours

ML277 - CAS# 1401242-74-7 size:10mg solid CAS Number: 418805-02-4ML277, CAS No. 1401242 74 7, is a potent activator of KCNQ1 (Kv7. 1) channels with >100 fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 M. KCNQ1 is a voltage gated potassium channel required for repolarization phase of the cardiac action potential. ML277 is the first selective and potent activator found, with an EC50 of 260 nM. Product information CAS Number: 1401242 74 7 Molecular Weight: 471. 59