Acalabrutinib - CAS# 1420477-60-6 size:10mg solid in the in vitro signaling

in the in vitro signaling assay on primary human CLL cells

Molecular Weight: 868

2016 May 12

HLY78 acts synergistically with Wnt in the embryonic development of zebrafish and increases the expression of the conserved hematopoietic stem cell (HSC) markers

InChi: InChI=1S/C12H21N3O2/c1-2-3-4-5-6-7-8-13-10-9-11(16)15-12(17)14-10/h9H

Acalabrutinib - CAS# 1420477-60-6 size:10mg solid in the in vitro signalingAcalabrutinib, also known as ACP 196, CAS No. 1420477 60 6, is an orally available inhibitor of Brutons tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP 196 inhibits the activity of BTK and prevents the activation of the B cell antigen receptor (BCR) signaling pathway. This prevents both B cell activation and BTK mediated activation of downstream survival pathways. This leads to an inhibition of the growth of