JNK Inhibitor VIII l H2O 4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide

4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide

3S)-3-hydroxy-3-(hydroxycarbamoyl)-2-(2-methylpropyl)propanamido]-2-phenylacetate

It acts most likely as a result of combined inhibition of DYRK1A and GSK3B

106(2):474-9

Clausen DM

JNK Inhibitor VIII l H2O 4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamideJNK Inhibitor VIII (TCS JNK 6o) is an inhibitor of c Jun N terminal kinases with IC50 of 45 nM and 160 nM for JNK 1 and JNK 2, respectively. JNK Inhibitor VIII (TCS JNK 6o) inihibits JNK 1, JNK 2, and JNK 3 with Ki of 2 nM, 4 nM and 52 nM, respectively. Product information CAS Number: 894804 07 0 Molecular Weight: 356. 38 Formula: C18H20N4O4 Synonym: TCS JNK 6o Chemical Name: N (4 Amino 5 cyano 6 ethoxy 2 pyridinyl) 2,5 dimethoxybenzeneacetamide