SN-38 isoside F 4-tetrahydroisoquinolin-2-ium benzenesulfonate

4-tetrahydroisoquinolin-2-ium benzenesulfonate

N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1

hydrolyzing long-chain fatty acid esters and thioesters) and promotes lipid storage in adipocytes

Solubility: DMSO: ≥ 43 mg/mL

(2011) Int J Oncol

SN-38 isoside F 4-tetrahydroisoquinolin-2-ium benzenesulfonateSN 38 is the active metabolite of irinotecan (an analog of camptothecin a topoisomerase I inhibitor); it is 1000 times more active than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN 38 relative to irinotecan varies from 2 to 2000 fold. SN38 is metabolized via glucoronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolization of irinotecan predicts irinotecan toxicity, as it cannot be