CCT128930 - CAS# 885499-61-6 iapine D8 fumarate Cardiomyocyte differentiation of pluripotent stem

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CCT128930 - CAS# 885499-61-6 iapine D8 fumarate Cardiomyocyte differentiation of pluripotent stemCCT128930 is a novel ATP competitive AKT inhibitor discovered using fragment and structure based approaches. It is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. CCT128930 exhibited marked antiproliferative activity and inhibited the phosphorylation of a range of AKT substrates in multiple tumor cell lines in vitro, consistent with AKT inhibition.