AZD-2281 - CAS# 763113-22-0 308 with EC50s of 0

with EC50s of 0

I-BET762 could be dosed to the mice by oral administration at 10-30 mg/kg once per day

It has ~125-fold greater selectivity over UCH-L1 (ubiquitin C-terminal hydrolase L1

4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide

Solubility: DMSO and water up to 50 mM

AZD-2281 - CAS# 763113-22-0 308 with EC50s of 0AZD 2281, also known as Olaparib or KU 59436, CAS No. 763113 22 0, is a small molecule inhibitor of the nuclear enzyme poly(ADP ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. AZD 2281 selectively binds to and inhibits PARP, inhibiting PARP mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA damaging agents and may reverse tumor cell