Pentoxifylline CS JNK 5a HCT-116 and MiaPaca cells

HCT-116 and MiaPaca cells

PubMed PMID: 24676877

Eubanks AL

ZLN005 is a useful chemical probe to study this target

It was developed as a replacement drug to combat bacteria that had acquired antibiotic resistance to commonly used antibiotics

Pentoxifylline CS JNK 5a HCT-116 and MiaPaca cellsPentoxifylline is a drug used to treat muscle pain in people with peripheral artery disease. Like other methylated xanthine derivatives, pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. It is being investigated for treatment of Alzheimer's disease. It is generic and sold under many brand names