SAE1 Polyclonal Antibody, 50ul ADME Alpha-2-macroglobulin is a protease inhibitor

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter

It is implicated in guidance of migrating neurons as well as axons during development

Mutations in this gene have been associated with leukodystrophy dysmyelinating with spastic paraparesis with or without dystonia

miscellaneous:The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein

involving ubiquitin conjugating enzymes and deubiquitinating enzymes

SAE1 Polyclonal Antibody, 50ul ADME Alpha-2-macroglobulin is a protease inhibitorPosttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO activating enzyme for the sumoylation of proteins.