MKX Polyclonal Antibody, 50ul Gene Editing Knockout mice lacking this gene

Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation| and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization

This gene encodes a potent cyclin-dependent kinase inhibitor

Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed: 20074560)

protein homology

Therefore| the encoded protein is thought to be an important part of functional kinetochores

MKX Polyclonal Antibody, 50ul Gene Editing Knockout mice lacking this geneThe protein encoded by this gene is an IRX family related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.