Cot(Phospho Ser400) Polyclonal Antibody, 20ul Cryogenic Vials ABCB7 encodes a half-transporter involved

ABCB7 encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains

It also interacts with multiple proteins including calmodulin| CABP1| enkurin| Na(+)-H+ exchange regulatory factor (NHERF )| interferon-induced GTP-binding protein (MX1)| ring finger protein 24 (RNF24)| and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1)

Related pseudogenes have been defined on chromosomes 8 and 20

Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy

Cot(Phospho Ser400) Polyclonal Antibody, 20ul Cryogenic Vials ABCB7 encodes a half-transporter involvedThis gene is an oncogene that encodes a member of the serine threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF kappaB. This protein was also found to promote the production of TNF alpha and IL 2 during T lymphocyte activation. This gene may also utilize a downstream