ALS2 Polyclonal Antibody, 50ul Variant Libraries A fairly broad range of

A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls| and repeat numbers in excess of 40 have been described as pathological

Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19

Several pseudogenes of this gene have been identified

which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus

Max-binding protein MNT is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth

ALS2 Polyclonal Antibody, 50ul Variant Libraries A fairly broad range ofThe protein encoded by this gene contains an ATS1 RCC1 like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics.