WNK1 Polyclonal Antibody, 100ul Diagnostic Probes & Oligos Guanine nucleotide exchange factors (GEFs)

Guanine nucleotide exchange factors (GEFs)

also known as the TEA domain (TEAD) family (TEAD1-4)

it mediates monoubiquitination of histone H2A 'Lys-119'

Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection

Enriched expression of this gene in embryonic mouse brain suggests that this gene may play a role in nervous system development

WNK1 Polyclonal Antibody, 100ul Diagnostic Probes & Oligos Guanine nucleotide exchange factors (GEFs)WNK1 encodes a member of the WNK subfamily of serine threonine protein kinases. The serine threonine protein kinase WNK1 may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full length