TGR5 Polyclonal Antibody, 20ul Cytokines this protein may play a

this protein may play a role in metal homeostasis

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Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene

An important paralog of this gene is SVOP

inducing its proteasomal degradation

TGR5 Polyclonal Antibody, 20ul Cytokines this protein may play aGPBAR1 encodes a member of the G protein coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.