CIR1A Rabbit Polyclonal Antibody, 100ul Antibody Humanization Reduced expression and rearrangement of

Reduced expression and rearrangement of this gene have been detected in various cancers

particularly in the nervous system

This protein functions in the degradation of type I

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a single transmembrane segment and two tandem intracytoplasmic catalytic domains

CIR1A Rabbit Polyclonal Antibody, 100ul Antibody Humanization Reduced expression and rearrangement ofThis gene encodes a WD40 repeat containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence. Alternative splicing results in multiple transcript variants.