PKR(Phospho Thr446) Polyclonal Antibody, 100ul Molecular Weight Markers It is expressed in the

It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions

This gene product

Alternative splicing results in multiple transcript variations

Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20

This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails

PKR(Phospho Thr446) Polyclonal Antibody, 100ul Molecular Weight Markers It is expressed in theThe protein encoded by this gene is a serine threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.