BID (Cleaved-Arg71) Rabbit Polyclonal Antibody, 50ul Serum that regulates endogenous p53 mRNA

that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA

This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment

The gene is located in a region deleted in pediatric rhabdoid tumors of the brain

The other two isoforms| p52Shc and p46Shc| link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex

10 µm PVDF membrane

BID (Cleaved-Arg71) Rabbit Polyclonal Antibody, 50ul Serum that regulates endogenous p53 mRNAIntact BH3 motif is required by BIK BID BAK BAD and BAX for their pro apoptotic activity and for their interaction with anti apoptotic members of the Bcl 2 family. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1 isoform 2 and isoform 4 induce ICE like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl 2. PTM: Phosphorylated upon DNA damage probably by