EDG-5 Polyclonal Antibody, 100ul[BT-AP02831] Cell Transfection The peptide binding cleft accommodates

The peptide binding cleft accommodates peptides of 10-30 residues

but their full length nature has not been described

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1

Sclerostin (SOST) is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists

including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM)

EDG-5 Polyclonal Antibody, 100ul[BT-AP02831] Cell Transfection The peptide binding cleft accommodatesS1PR2 encodes a member of the G protein coupled receptors, as well as the EDG family of proteins. The encoded protein (sphingosine 1 phosphate receptor 2) is a receptor for sphingosine 1 phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in S1PR2 have been associated with congenital profound deafness.