Phospho-Akt2 (S474) Polyclonal Antibody, 50ul Antibodies 5-triphosphate (PIP3)

5-triphosphate (PIP3)

Polymorphism within this gene is associated with variable ability to metabolize mephenytoin

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May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier

Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP)

Phospho-Akt2 (S474) Polyclonal Antibody, 50ul Antibodies 5-triphosphate (PIP3)AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine threonine kinases containing SH2 like (Src homology 2 like) domains. AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT serine threonine kinase 2 is a general protein kinase capable of