Shc(Phospho Tyr427) Polyclonal Antibody, 50ul Cell Culture Flasks is amplified in the mouse

is amplified in the mouse transformed 3T3 cell line

The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos

a cytoplasmic signaling molecule that mediates effects of insulin

These receptors are composed of an N-terminal glycosylated ligand-binding domain

subcellular location:Localized at the plasma membrane in areas of cell-cell contacts and at the cell surface of PMN

Shc(Phospho Tyr427) Polyclonal Antibody, 50ul Cell Culture Flasks is amplified in the mouseThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation.