Tuberin Polyclonal Antibody, 50ul[BT-AP09287] Cell Function Analysis This protein plays a role

This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development

Impaired spindle checkpoint function has been found in many forms of cancer

and transcription factor erythroblastosis virus E26 oncogene homolog 1

NANOG plays a central role in regulating self-renewal in pluripotent stem cells and tumor cells

The functions of human sirtuins have not yet been determined

Tuberin Polyclonal Antibody, 50ul[BT-AP09287] Cell Function Analysis This protein plays a roleMutations in TSC2 lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.