Histone H3 Monoclonal Antibody, 100ul Contamination Detection & Removal also known as the TCP1

also known as the TCP1 ring complex (TRiC)

This gene is aberrantly methylated in pancreatic cancer

Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity

The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade

and by CTNNB1 and TCF family members in Wnt signaling

Histone H3 Monoclonal Antibody, 100ul Contamination Detection & Removal also known as the TCP1Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin