PCB Polyclonal Antibody, 50ul Bottles Mutations in EPHA2 are the

Mutations in EPHA2 are the cause of certain genetically-related cataract disorders

It is expressed in the tissue and circulating myeloid leukocytes

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This secreted protein undergoes a complex proteolytic maturation

According to PubMed:97066888

PCB Polyclonal Antibody, 50ul Bottles Mutations in EPHA2 are thePC encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase