Rb Polyclonal Antibody, 100ul[BT-AP07690] Microplate Mixer The encoded protein is active

The encoded protein is active in bulk vitamin C transport involving epithelial surfaces

Contains 2 TPR repeats

making it ideal for labs looking to increase throughput and save time

PTM:Ubiquitinated

The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity

Rb Polyclonal Antibody, 100ul[BT-AP07690] Microplate Mixer The encoded protein is activeThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.