IRE1 Alpha Monoclonal Antibody, 50ul Sealing Film The ubiquitination factor E4A is

The ubiquitination factor E4A is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin

which thus leads to the constitutive activation of MAPK14

The enzyme also metabolizes some steroids and carcinogens

This gene encodes an alpha 1 subunit

The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths

IRE1 Alpha Monoclonal Antibody, 50ul Sealing Film The ubiquitination factor E4A isThe protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum based stress signals.