Tuberin Polyclonal Antibody, 50ul[BT-AP09285] Cellular Function Assays the members of the KappaB-Ras

the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65

HDAC5 is thought to be associated with colon cancer

The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade

Related pseudogenes have been identified on chromosomes 3 and 10

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Tuberin Polyclonal Antibody, 50ul[BT-AP09285] Cellular Function Assays the members of the KappaB-RasMutations in TSC2 (tuberous sclerosis 2) lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.