PERK Polyclonal Antibody, 100ul[BT-AP07065] Antibodies GO annotations related to this

GO annotations related to this gene include nucleic acid binding and exonuclease activity

Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2)

and may play a role in transcriptional regulation

which is known as a precursor of the cornified cell envelope

A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases

PERK Polyclonal Antibody, 100ul[BT-AP07065] Antibodies GO annotations related to thisThe protein encoded by EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3) phosphorylates the alpha subunit of eukaryotic translation initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is